Role of keratins in liver disease and cell signaling

강좌 소개

Keratins 8 and 18 (K8 K18) are heteropolymeric intermediate filament (IF) phospho glycoproteins in simple type epithelia K8 K18 protect hepatocytes from apoptosis and their mutations predispose to liver disease We previously reported the disease association of K8 K18 This work was based on our findings in transgenic mice which overexpressed a dominant negative mutant of human K18 The mice developed chronic hepatitis fragile hepatocytes with disrupted filament and increased susceptibility to drug induced liver injury This result led us to hypothesize that some cases of human hepatitis may be associated with K8 and or K18 mutations We tested and confirmed this hypothesis with findings that have been described in several publications Our findings to date indicate that K8 or K18 mutations pose a risk factor for developing liver disease Such mutations are found in 12 of all patients with liver disease Another area of research focuses on studying the in vivo function of K18 glycosyl

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구남온

등록일

2009-11-26